CCNB1IP1

Across TCGA patient cohorts, CCNB1IP1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCNB1IP1-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and eIF4E. Each is linked with CCNB1IP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCNB1IP1-to-partner and partner-to-CCNB1IP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by CCNB1IP1-low versus CCNB1IP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCNB1IP1→partner) and Y-score (partner→CCNB1IP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.115	-3.143	.011	.018	3	1
UCEC	EGFR_pY1068 →	-0.245	-2.000	.030	.032	3	1
UCEC	eIF4E →	+0.205	+3.807	.031	<.001	3	1
UCEC	ERK2 →	+0.260	+3.321	.002	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.197	-2.999	.009	.035	3	1
UCEC	JNK2 →	+0.257	+2.196	.004	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

14-3-3_beta by CCNB1IP1 expression — UCEC

Explore this box plot interactively →