CCNA2

Across TCGA patient cohorts, CCNA2 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCNA2-associated genes across cancer lineages are eEF2, EGFR_pY1068, and eIF4G. Each is linked with CCNA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCNA2-to-partner and partner-to-CCNA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CCNA2-low versus CCNA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCNA2→partner) and Y-score (partner→CCNA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.349	+2.459	.009	.018	3	1
UCEC	EGFR_pY1068 →	-0.254	-1.765	.006	.014	3	1
UCEC	eIF4G →	+0.284	+2.000	.014	.029	3	1
UCEC	ERK2 →	+0.213	+2.000	.003	.009	3	1
UCEC	FoxM1 →	+0.205	+2.169	.034	.003	3	1
UCEC	JNK_pT183_Y185 →	-0.222	-3.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

eEF2 by CCNA2 expression — UCEC

Explore this box plot interactively →