CCN6

Across TCGA pan-cancer cohorts, CCN6 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CCN6 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher CCN6 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CCN6 expression acts as an unfavorable survival marker.

BRCA, SKCM, and SCLC are the cancer types where CCN6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.350	0.924	<.001	36	view →
SKCM	OS	Median	III,IV	0.230	0.721	.004	11	view →
SCLC	OS	Median	All	0.082	0.822	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CCN6–BRCA (OS)

Open the BRCA breakdown →