CCN6

Across TCGA cell cohorts, CCN6 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCN6-associated genes across cancer lineages are ENPP6, SSMEM1, and OR1L6. Each is linked with CCN6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCN6-to-partner and partner-to-CCN6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ENPP6 grouped by CCN6-low versus CCN6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCN6→partner) and Y-score (partner→CCN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ENPP6 →	+0.040	+3.793	.001	.007	3	1
LARGE_INTESTINE	SSMEM1 →	+0.030	+3.707	<.001	.009	3	1
LARGE_INTESTINE	OR1L6 →	+0.022	+4.437	<.001	.004	3	1
LARGE_INTESTINE	FAM205A →	+0.025	+4.614	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ENPP6 by CCN6 expression — LARGE_INTESTINE

Explore this box plot interactively →