CCN4

Across TCGA pan-cancer cohorts, CCN4 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of CCN4’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where CCN4 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CCN4 is over-expressed in tumor.

LSCC, PDAC, and LUAD are the cancer types where CCN4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCN4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Female	All	+0.893	<.001	7	view →
PDAC	All	All	+0.524	.003	4	view →
LUAD	All	All	+0.417	<.001	4	view →
OV	All	All	+1.147	.037	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

CCN4–LSCC

Open the LSCC breakdown →