CCN4

Across TCGA patient cohorts, CCN4 mutation is significantly associated with the RNA expression of many other genes, with 1,958 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCN4-associated genes across cancer lineages are TPI1, COX7A2, and ALDOA. Each is linked with CCN4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCN4-to-partner and partner-to-CCN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TPI1 grouped by CCN4-low versus CCN4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCN4→partner) and Y-score (partner→CCN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TPI1 →	+0.377	+2.115	.006	<.001	3	3
UCEC	COX7A2 →	+0.286	+2.043	.006	.004	3	3
UCEC	ALDOA →	+0.551	+2.432	<.001	<.001	3	2
UCEC	DLAT →	+0.567	+2.280	<.001	<.001	3	2
UCEC	BAG3 →	+0.648	+2.115	<.001	<.001	3	2
UCEC	DDAH1 →	+0.548	+2.108	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,958 associations by consensus.

TPI1 by CCN4 expression — UCEC

Explore this box plot interactively →