CCN4

Across TCGA patient cohorts, CCN4 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCN4-associated genes across cancer lineages are Claudin-7, Gab2, and Ku80. Each is linked with CCN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCN4-to-partner and partner-to-CCN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Claudin-7 grouped by CCN4-low versus CCN4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCN4→partner) and Y-score (partner→CCN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Claudin-7 →	+0.276	+2.493	<.001	.010	3	2
UCEC	Gab2 →	+0.271	+1.584	.023	.009	3	2
UCEC	Ku80 →	+0.180	+1.598	.023	.006	3	2
UCEC	P-Cadherin →	-0.106	-1.874	.028	.049	3	2
UCEC	4E-BP1 →	+0.221	+2.700	.014	.005	3	2
STAD	Cyclin-E2 →	+0.159	+2.828	.032	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Claudin-7 by CCN4 expression — SKCM

Explore this box plot interactively →