CCN4

Across TCGA cell cohorts, CCN4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,289 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CCN4-associated GO terms across cancer lineages are Maintenance of protein location in cell, Protein secretion, and Regulation of hydrolase activity. Each is linked with CCN4 in more than 7 cancer types. Because this analysis shows association rather than direction, both CCN4-to-partner and partner-to-CCN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maintenance of protein location in cell grouped by CCN4-low versus CCN4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCN4→partner) and Y-score (partner→CCN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Maintenance of protein location in cell →	+0.158	+2.991	<.001	<.001	3	8
BONE	Protein secretion →	+0.072	+2.133	.006	.003	3	7
BONE	Regulation of hydrolase activity →	+0.068	+2.947	<.001	<.001	3	7
BONE	Maintenance of protein location →	+0.156	+2.874	<.001	<.001	3	6
BONE	Elastin metabolic process →	+0.259	+2.309	<.001	<.001	3	6
BONE	Protein localization to endoplasmic reticulum →	+0.136	+3.296	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,289 associations by consensus.

Maintenance of protein location in cell by CCN4 expression — BONE

Explore this box plot interactively →