CCN4

Across TCGA cell cohorts, CCN4 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCN4-associated genes across cancer lineages are DEFB119, MS4A5, and MMD2. Each is linked with CCN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCN4-to-partner and partner-to-CCN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB119 grouped by CCN4-low versus CCN4-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCN4→partner) and Y-score (partner→CCN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DEFB119 →	+0.231	+5.000	<.001	.006	3	1
BLOOD_Leukemia	MS4A5 →	+0.061	+4.969	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	MMD2 →	+0.036	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	UTF1 →	+0.226	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	USP17L22 →	+0.013	+5.357	<.001	.003	3	1
LARGE_INTESTINE	SLC22A14 →	+0.298	+3.314	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

DEFB119 by CCN4 expression — PANCREAS

Explore this box plot interactively →