CCN2

Across TCGA pan-cancer cohorts, CCN2 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CCN2 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CCN2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CCN2 expression acts as an unfavorable survival marker.

CCRCC, HNSC, and LSCC are the cancer types where CCN2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.128	0.952	.003	49	view →
HNSC	OS	Median	All	0.479	1.000	.049	12	view →
LSCC	OS	Median	II,III,IV	0.899	1.000	.013	11	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CCN2–CCRCC (DFS)

Open the CCRCC breakdown →