CCN2

Across TCGA patient cohorts, CCN2 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCN2-associated genes across cancer lineages are FASN, JNK2, and Ku80. Each is linked with CCN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCN2-to-partner and partner-to-CCN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by CCN2-low versus CCN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCN2→partner) and Y-score (partner→CCN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.333	+2.115	.021	.017	3	1
UCEC	JNK2 →	+0.207	+1.710	.004	.025	3	1
UCEC	Ku80 →	+0.234	+2.125	.007	.010	3	1
UCEC	MEK1 →	+0.429	+3.000	.001	<.001	3	1
UCEC	Notch1 →	+0.171	+1.847	<.001	.008	3	1
UCEC	p38-MAPK →	-0.194	-3.446	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

FASN by CCN2 expression — UCEC

Explore this box plot interactively →