CCN2

Across TCGA cell cohorts, CCN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,689 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CCN2-associated GO terms across cancer lineages are Regulation of focal adhesion assembly, Regulation of cell-substrate junction assembly, and Positive regulation of supramolecular fiber organization. Each is linked with CCN2 in more than 13 cancer types. Because this analysis shows association rather than direction, both CCN2-to-partner and partner-to-CCN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of focal adhesion assembly grouped by CCN2-low versus CCN2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCN2→partner) and Y-score (partner→CCN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of focal adhesion assembly →	+0.170	+4.825	<.001	<.001	3	14
BONE	Regulation of cell-substrate junction assembly →	+0.170	+4.825	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Positive regulation of supramolecular fiber organization →	+0.093	+3.710	.003	<.001	3	13
BONE	Positive regulation of actin filament bundle assembly →	+0.208	+4.672	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Transport of virus →	+0.269	+3.982	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Intracellular transport of virus →	+0.269	+3.982	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,689 associations by consensus.

Regulation of focal adhesion assembly by CCN2 expression — BONE

Explore this box plot interactively →