CCN1

Across TCGA patient cohorts, CCN1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCN1-associated genes across cancer lineages are ERK2, JNK2, and Notch1. Each is linked with CCN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCN1-to-partner and partner-to-CCN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by CCN1-low versus CCN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCN1→partner) and Y-score (partner→CCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.187	+2.321	.026	.034	3	1
UCEC	JNK2 →	+0.241	+2.807	.005	.003	3	1
UCEC	Notch1 →	+0.143	+2.183	.020	.033	3	1
UCEC	p27_pT198 →	+0.098	+2.115	.037	.019	3	1
UCEC	Annexin-1 →	+0.602	+3.019	.008	.019	3	1
UCEC	S6_pS240_S244 →	+0.365	+3.000	.039	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

ERK2 by CCN1 expression — UCEC

Explore this box plot interactively →