CCN1

Across TCGA cell cohorts, CCN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,507 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CCN1-associated GO terms across cancer lineages are Alpha-beta T cell lineage commitment, Substrate adhesion-dependent cell spreading, and Wound healing. Each is linked with CCN1 in more than 14 cancer types. Because this analysis shows association rather than direction, both CCN1-to-partner and partner-to-CCN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Alpha-beta T cell lineage commitment grouped by CCN1-low versus CCN1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCN1→partner) and Y-score (partner→CCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Alpha-beta T cell lineage commitment →	+0.233	+3.118	<.001	.001	3	15
BONE	Substrate adhesion-dependent cell spreading →	+0.182	+4.023	<.001	<.001	3	15
BONE	Wound healing →	+0.143	+4.861	<.001	<.001	3	15
BONE	Positive regulation of stress fiber assembly →	+0.204	+4.978	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Regulation of plasminogen activation →	+0.336	+4.542	<.001	<.001	3	15
BONE	Regulation of cell-substrate adhesion →	+0.127	+3.506	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,507 associations by consensus.

Alpha-beta T cell lineage commitment by CCN1 expression — LUNG_SCLC

Explore this box plot interactively →