CCN1

Across TCGA cell cohorts, CCN1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CCN1-associated genes across cancer lineages are KIF2B, OR10D3, and LCE1C. Each is linked with CCN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCN1-to-partner and partner-to-CCN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIF2B grouped by CCN1-low versus CCN1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCN1→partner) and Y-score (partner→CCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	KIF2B →	+0.040	+4.981	<.001	.008	3	1
CNS	OR10D3 →	+0.022	+5.321	<.001	.005	3	1
BLOOD_Leukemia	LCE1C →	+0.432	+4.922	.002	.009	3	1
BLOOD_Leukemia	SLC5A8 →	+0.182	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR10A6 →	+0.044	+5.201	<.001	.006	3	1
BLOOD_Leukemia	CFHR2 →	+0.395	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

KIF2B by CCN1 expression — CNS

Explore this box plot interactively →