CCM2

Across TCGA patient cohorts, CCM2 mutation is significantly associated with the immune_cell of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCM2-associated genes across cancer lineages are CD4+ Tcm, CD8+ naive T-cells, and Class-switched memory B-cells. Each is linked with CCM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCM2-to-partner and partner-to-CCM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD4+ Tcm grouped by CCM2-low versus CCM2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCM2→partner) and Y-score (partner→CCM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CD4+ Tcm →	+0.008	+3.896	.009	.016	3	1
UCEC	CD8+ naive T-cells →	+0.032	+1.906	.002	.029	3	1
UCEC	Class-switched memory B-cells →	-0.050	-2.774	.026	.033	3	1
UCEC	Endothelial cells →	-0.035	-2.459	.018	.002	3	1
UCEC	lymphatic Endothelial cells →	-0.023	-3.544	.012	.002	2	2
UCEC	Melanocytes →	-0.009	-1.903	.020	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

CD4+ Tcm by CCM2 expression — LUAD

Explore this box plot interactively →