CCM2

Across TCGA cell cohorts, CCM2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,259 significant associations in total. CNS shows the largest number of these associations.

The most reproducible CCM2-associated GO terms across cancer lineages are 2-oxoglutarate decarboxylation to succinyl-CoA, Protein-containing complex disassembly, and Regulation of anaphase-promoting complex-dependent catabolic process. Each is linked with CCM2 in more than 13 cancer types. Because this analysis shows association rather than direction, both CCM2-to-partner and partner-to-CCM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 2-oxoglutarate decarboxylation to succinyl-CoA grouped by CCM2-low versus CCM2-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCM2→partner) and Y-score (partner→CCM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	2-oxoglutarate decarboxylation to succinyl-CoA →	+0.155	+1.007	.004	.001	3	14
LUNG_NSCLC_LUSC	Protein-containing complex disassembly →	+0.099	+1.244	<.001	<.001	3	13
BLOOD_Leukemia	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.096	+1.101	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Actin filament depolymerization →	+0.213	+1.125	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Protein depolymerization →	+0.101	+0.815	<.001	.001	3	12
PANCREAS	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.114	+0.740	.001	.001	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,259 associations by consensus.

2-oxoglutarate decarboxylation to succinyl-CoA by CCM2 expression — OESOPHAGUS

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