CCL5

Across TCGA patient cohorts, CCL5 mutation is significantly associated with the RNA expression of many other genes, with 144 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCL5-associated genes across cancer lineages are SNORD114-5, FAM32BP, and FRG2. Each is linked with CCL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCL5-to-partner and partner-to-CCL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD114-5 grouped by CCL5-low versus CCL5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCL5→partner) and Y-score (partner→CCL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNORD114-5 →	+0.213	+4.890	<.001	.002	3	1
UCEC	FAM32BP →	+0.360	+3.332	.003	.005	3	1
UCEC	FRG2 →	+0.275	+2.300	.004	.009	3	1
UCEC	RNU6-574P →	+0.841	+3.535	.003	.005	3	1
UCEC	MIR128-2 →	+0.187	+3.879	<.001	.009	3	1
UCEC	TRAV8-6 →	+0.741	+3.343	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 144 associations by consensus.

SNORD114-5 by CCL5 expression — UCEC

Explore this box plot interactively →