CCL5

Across TCGA patient cohorts, CCL5 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCL5-associated genes across cancer lineages are JNK2, Caspase-8, and MEK1. Each is linked with CCL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCL5-to-partner and partner-to-CCL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by CCL5-low versus CCL5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCL5→partner) and Y-score (partner→CCL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.248	+2.817	.022	.036	3	1
UCEC	Caspase-8 →	-0.274	-2.973	.047	.035	3	1
UCEC	MEK1 →	+0.470	+3.169	.019	.020	2	1
UCEC	TFRC →	+0.706	+3.169	.015	.020	2	1
UCEC	C-Raf →	+0.196	+3.169	.012	.020	2	1
UCEC	VHL →	-1.202	-3.169	.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

JNK2 by CCL5 expression — UCEC

Explore this box plot interactively →