CCL3L3

Across TCGA pan-cancer cohorts, CCL3L3 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated CCL3L3 data layer compared with 2 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher CCL3L3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CCL3L3 expression acts as an unfavorable survival marker, although some lineages such as SKCM and LUAD show a favorable association.

SKCM, UVM, and LUAD are the cancer types where CCL3L3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.490	0.245	<.001	55	view →
UVM	DFS	Tertile	II,III,IV	0.242	0.667	.001	50	view →
LUAD	OS	Median	II,III,IV	0.699	0.463	<.001	40	view →
KIRP	DFS	Tertile	IV	0.042	0.811	.001	36	view →
LGG	OS	Quartile	All	0.910	0.696	<.001	25	view →
GBM	OS	Quartile	All	0.206	0.519	.015	15	view →
OV	OS	Tertile	III,IV	0.265	0.350	.014	14	view →
CESC	OS	Median	II,III,IV	0.753	0.901	.010	12	view →
ACC	OS	Quartile	IV	0.414	0.754	.006	12	view →
LAML	DFS	Tertile	All	0.183	0.581	.002	12	view →
COAD	OS	Tertile	All	0.955	0.805	.008	11	view →
THYM	OS	Tertile	II,III,IV	0.867	1.000	.022	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

CCL3L3–SKCM (OS)

Open the SKCM breakdown →