CCL3

Across TCGA cell cohorts, CCL3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,170 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CCL3-associated GO terms across cancer lineages are Toll-like receptor signaling pathway, Negative regulation of translational initiation in response to stress, and Cytoplasmic pattern recognition receptor signaling pathway. Each is linked with CCL3 in more than 5 cancer types. Because this analysis shows association rather than direction, both CCL3-to-partner and partner-to-CCL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Toll-like receptor signaling pathway grouped by CCL3-low versus CCL3-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCL3→partner) and Y-score (partner→CCL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Toll-like receptor signaling pathway →	+0.047	+2.420	.001	.009	3	6
UPPER_AERODIGESTIVE_TRACT	Negative regulation of translational initiation in response to stress →	+0.086	+0.716	<.001	.002	3	5
BLOOD_Lymphoma	Cytoplasmic pattern recognition receptor signaling pathway →	+0.069	+3.427	.001	<.001	3	5
BLOOD_Leukemia	Positive regulation of innate immune response →	+0.033	+3.148	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	Oncogene-induced cell senescence →	+0.119	+0.723	.004	.002	3	5
CNS	Response to 3,3',5-triiodo-L-thyronine →	-0.129	-0.353	.001	.005	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,170 associations by consensus.

Toll-like receptor signaling pathway by CCL3 expression — BLOOD_Lymphoma

Explore this box plot interactively →