CCL22

Across TCGA cell cohorts, CCL22 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,398 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CCL22-associated GO terms across cancer lineages are NMDA selective glutamate receptor signaling pathway, Positive regulation of iron ion transport, and Positive regulation of iron ion transmembrane transport. Each is linked with CCL22 in more than 6 cancer types. Because this analysis shows association rather than direction, both CCL22-to-partner and partner-to-CCL22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NMDA selective glutamate receptor signaling pathway grouped by CCL22-low versus CCL22-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCL22→partner) and Y-score (partner→CCL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NMDA selective glutamate receptor signaling pathway →	+0.201	+0.648	<.001	<.001	3	7
OVARY	Positive regulation of iron ion transport →	+1.771	+0.148	<.001	.002	3	7
OVARY	Positive regulation of iron ion transmembrane transport →	+1.771	+0.148	<.001	.002	3	7
BLOOD_Leukemia	Regulation of tumor necrosis factor (ligand) superfamily member 11 production →	+0.995	+1.736	<.001	.004	3	7
UPPER_AERODIGESTIVE_TRACT	Peptidyl-lysine acetylation →	-0.064	-0.675	.001	.005	3	6
UPPER_AERODIGESTIVE_TRACT	Regulation of endoplasmic reticulum unfolded protein response →	+0.080	+0.742	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,398 associations by consensus.

NMDA selective glutamate receptor signaling pathway by CCL22 expression — PANCREAS

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