CCL1

Across TCGA patient cohorts, CCL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,805 significant associations in total. THCA shows the largest number of these associations.

The most reproducible CCL1-associated GO terms across cancer lineages are Negative regulation of interleukin-10 production, T cell proliferation, and Tolerance induction dependent upon immune response. Each is linked with CCL1 in more than 22 cancer types. Because this analysis shows association rather than direction, both CCL1-to-partner and partner-to-CCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of interleukin-10 production grouped by CCL1-low versus CCL1-high in UVM.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCL1→partner) and Y-score (partner→CCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	Negative regulation of interleukin-10 production →	+0.073	+0.060	<.001	.004	3	23
UVM	T cell proliferation →	+0.050	+0.136	<.001	<.001	3	23
UVM	Tolerance induction dependent upon immune response →	+0.120	+0.109	<.001	.004	3	22
BLCA	Peptide antigen assembly with MHC class II protein complex →	+0.132	+0.178	<.001	<.001	3	22
UVM	Positive regulation of T cell tolerance induction →	+0.113	+0.095	<.001	.004	3	22
TGCT	Interleukin-2 production →	+0.045	+0.692	<.001	<.001	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,805 associations by consensus.

Negative regulation of interleukin-10 production by CCL1 expression — UVM

Explore this box plot interactively →