Across TCGA cell cohorts, CCIN mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CCIN-associated genes across cancer lineages are OR4D6, PTPRT, and CCL21. Each is linked with CCIN in more than 1 cancer types. Because this analysis shows association rather than direction, both CCIN-to-partner and partner-to-CCIN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCIN→partner) and Y-score (partner→CCIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR4D6 →	+0.012	+4.807	<.001	.003	3	1
OVARY	PTPRT →	+0.121	+4.450	<.001	.004	3	1
BLOOD_Leukemia	CCL21 →	+0.127	+3.705	<.001	.007	3	1
BLOOD_Leukemia	GUCA1C →	+0.023	+4.384	<.001	.006	3	1
BLOOD_Leukemia	TCF23 →	+1.378	+3.855	<.001	.007	3	1
BLOOD_Leukemia	ETDB →	+0.054	+3.551	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

CCIN survival (RNA) · tumor vs normal (RNA) · all CCIN data types