CCDC9

Across TCGA patient cohorts, CCDC9 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC9-associated genes across cancer lineages are eIF4E, A-Raf_pS299, and MAPK_pT202_Y204. Each is linked with CCDC9 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC9-to-partner and partner-to-CCDC9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CCDC9-low versus CCDC9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC9→partner) and Y-score (partner→CCDC9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.181	+2.321	.033	.034	3	2
UCEC	A-Raf_pS299 →	-0.121	-1.906	.011	.016	3	1
UCEC	MAPK_pT202_Y204 →	-0.465	-2.222	.013	.010	3	1
UCEC	MEK1_p_S217_S221 →	-0.217	-2.115	.048	.017	3	1
UCEC	NDRG1_pT346 →	-0.477	-2.584	.015	.010	3	1
UCEC	Notch1 →	+0.182	+3.472	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

eIF4E by CCDC9 expression — UCEC

Explore this box plot interactively →