CCDC9

Across TCGA cell cohorts, CCDC9 mutation is significantly associated with the RNA expression of many other genes, with 310 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCDC9-associated genes across cancer lineages are SIRPD, SERPINA2, and PPIAL4E. Each is linked with CCDC9 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC9-to-partner and partner-to-CCDC9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIRPD grouped by CCDC9-low versus CCDC9-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC9→partner) and Y-score (partner→CCDC9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SIRPD →	+0.065	+5.029	<.001	.006	3	1
LUNG_SCLC	SERPINA2 →	+0.045	+5.029	<.001	.006	3	1
LUNG_SCLC	PPIAL4E →	+0.036	+5.643	<.001	.002	3	1
LARGE_INTESTINE	EIF3L →	+0.634	+3.237	<.001	.003	3	1
LARGE_INTESTINE	CCDC113 →	+0.855	+3.237	.002	.003	3	1
LARGE_INTESTINE	SEMA3G →	+0.729	+3.064	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 310 associations by consensus.

SIRPD by CCDC9 expression — LUNG_SCLC

Explore this box plot interactively →