CCDC89

Across TCGA patient cohorts, CCDC89 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC89-associated genes across cancer lineages are MSH2, INPP4B, and mTOR_pS2448. Each is linked with CCDC89 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC89-to-partner and partner-to-CCDC89 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by CCDC89-low versus CCDC89-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC89→partner) and Y-score (partner→CCDC89) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.253	-2.973	.009	.035	3	2
UCEC	INPP4B →	-0.302	-2.321	.027	.033	3	1
UCEC	mTOR_pS2448 →	-0.181	-2.222	.004	.011	3	1
UCEC	mTOR →	-0.215	-1.700	.001	.044	3	1
UCEC	NF-kB-p65_pS536 →	-0.464	-2.312	.016	.034	3	1
UCEC	PCNA →	+0.274	+2.321	.002	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MSH2 by CCDC89 expression — UCEC

Explore this box plot interactively →