Across TCGA pan-cancer cohorts, CCDC85C mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CCDC85C’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where CCDC85C mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CCDC85C is over-expressed in tumor, although a few such as CCRCC and LUAD show the opposite, repressed pattern.

CCRCC, LUAD, and LSCC are the cancer types where CCDC85C tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC85C mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	IV	−0.556	<.001	11	view →
LUAD	All	All	−0.170	<.001	4	view →
LSCC	All	All	+0.135	.002	4	view →
PDAC	All	II,III,IV	−0.276	.013	2	view →
HNSC	Male	All	−0.187	.037	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: CCDC85C RNA expression & survival · all CCDC85C data types