CCDC80

Across TCGA patient cohorts, CCDC80 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC80-associated genes across cancer lineages are Caspase-7-cleavedD198, eEF2, and Notch1. Each is linked with CCDC80 in more than 3 cancer types. Because this analysis shows association rather than direction, both CCDC80-to-partner and partner-to-CCDC80 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CCDC80-low versus CCDC80-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC80→partner) and Y-score (partner→CCDC80) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Caspase-7-cleavedD198 →	+0.754	+2.824	.003	.036	1	4
UCEC	eEF2 →	+0.279	+2.459	.014	.018	3	2
UCEC	Notch1 →	+0.131	+2.009	.003	.005	3	2
UCEC	Rictor_pT1135 →	-0.083	-1.777	.011	.002	3	2
UCEC	TIGAR →	+0.137	+1.550	.004	.004	3	2
UCEC	VEGFR2 →	+0.269	+2.415	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Caspase-7-cleavedD198 by CCDC80 expression — LUAD

Explore this box plot interactively →