CCDC80

Across TCGA cell cohorts, CCDC80 mutation is significantly associated with the RNA expression of many other genes, with 143 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCDC80-associated genes across cancer lineages are ZPBP2, PHF5A, and KPNA3. Each is linked with CCDC80 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC80-to-partner and partner-to-CCDC80 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZPBP2 grouped by CCDC80-low versus CCDC80-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC80→partner) and Y-score (partner→CCDC80) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ZPBP2 →	+0.424	+3.882	.001	.003	3	2
LARGE_INTESTINE	PHF5A →	+0.505	+3.502	.004	.001	3	1
LARGE_INTESTINE	KPNA3 →	+0.580	+3.321	.001	.003	3	1
LARGE_INTESTINE	NUP155 →	+0.767	+3.588	<.001	<.001	3	1
LARGE_INTESTINE	WRAP73 →	+0.583	+3.169	.001	.009	3	1
LARGE_INTESTINE	SDHB →	+0.501	+2.451	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 143 associations by consensus.

ZPBP2 by CCDC80 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →