CCDC80

Across TCGA cell cohorts, CCDC80 mutation is significantly associated with the mutation status of many other genes, with 5,698 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCDC80-associated genes across cancer lineages are BICRA, ABCC8, and AFF3. Each is linked with CCDC80 in more than 4 cancer types. Because this analysis shows association rather than direction, both CCDC80-to-partner and partner-to-CCDC80 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BICRA grouped by CCDC80-low versus CCDC80-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC80→partner) and Y-score (partner→CCDC80) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	BICRA →	+3.925	+5.337	<.001	<.001	1	5
BLOOD_Leukemia	ABCC8 →	+3.078	+3.847	<.001	<.001	1	5
BLOOD_Lymphoma	AFF3 →	+5.247	+4.429	.005	.005	1	5
LARGE_INTESTINE	PIK3CD →	+4.767	+2.992	<.001	<.001	1	5
BLOOD_Leukemia	KANK1 →	+2.662	+2.887	.005	.005	1	5
BLOOD_Lymphoma	SYNM →	+4.247	+4.554	.001	.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,698 associations by consensus.

BICRA by CCDC80 expression — BLOOD_Lymphoma

Explore this box plot interactively →