CCDC78

Across TCGA cell cohorts, CCDC78 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CCDC78-associated genes across cancer lineages are FCN2, GJD2, and KRT6C. Each is linked with CCDC78 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC78-to-partner and partner-to-CCDC78 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCN2 grouped by CCDC78-low versus CCDC78-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC78→partner) and Y-score (partner→CCDC78) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FCN2 →	+0.028	+4.000	<.001	<.001	3	2
BREAST	GJD2 →	+0.313	+4.199	<.001	.007	3	2
KIDNEY	KRT6C →	+0.006	+5.000	<.001	.005	3	1
KIDNEY	PNLIPRP1 →	+0.043	+5.000	<.001	.005	3	1
KIDNEY	OR52K1 →	+0.060	+5.000	<.001	.005	3	1
KIDNEY	PRAMEF25 →	+0.023	+5.000	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

FCN2 by CCDC78 expression — LARGE_INTESTINE

Explore this box plot interactively →