CCDC74A

Across TCGA pan-cancer cohorts, CCDC74A Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated CCDC74A data layer compared with 25 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher CCDC74A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CCDC74A expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

ESCA, HNSC, and BRCA are the cancer types where CCDC74A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.161	0.707	<.001	48	view →
HNSC	DFS	Median	All	0.122	0.696	<.001	45	view →
BRCA	OS	Median	II,III,IV	0.165	0.913	<.001	32	view →
LIHC	DFS	Median	All	0.044	0.553	<.001	12	view →
LUAD	OS	Median	All	0.437	0.813	.002	10	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
UCEC	DFS	Median	All	1.000	0.637	.048	2	view →
SKCM	DFS	Median	II,III,IV	0.883	0.681	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

CCDC74A–ESCA (OS)

Open the ESCA breakdown →