Across TCGA pan-cancer cohorts, CCDC73 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CCDC73 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CCDC73 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated CCDC73 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, ACC, and ESCA are the cancer types where CCDC73 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.973	0.613	.003	22	view →
ACC	OS	Median	All	0.151	0.632	.006	12	view →
ESCA	OS	Median	II,III,IV	0.216	0.702	.018	6	view →
SKCM	OS	Median	III,IV	0.896	0.318	.004	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: CCDC73 tumor-vs-normal RNA expression · all CCDC73 data types