CCDC70

Across TCGA pan-cancer cohorts, CCDC70 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CCDC70’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CCDC70 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CCDC70 is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

COAD, LSCC, and HNSC are the cancer types where CCDC70 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC70 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	+0.607	<.001	11	view →
LSCC	All	II,III,IV	+0.251	<.001	9	view →
HNSC	All	III,IV	+0.190	<.001	6	view →
CCRCC	All	All	+0.126	.017	2	view →
LUAD	All	II,III,IV	−0.147	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CCDC70–COAD

Open the COAD breakdown →