CCDC70

Across TCGA patient cohorts, CCDC70 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC70-associated genes across cancer lineages are MEK1, VHL, and c-Met_pY1235. Each is linked with CCDC70 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC70-to-partner and partner-to-CCDC70 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CCDC70-low versus CCDC70-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC70→partner) and Y-score (partner→CCDC70) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.520	+3.000	.013	.037	3	1
UCEC	VHL →	-0.892	-3.000	.023	.036	3	1
UCEC	c-Met_pY1235 →	+0.090	+3.009	.036	.019	3	1
UCEC	Rab25 →	-0.405	-3.000	.034	.037	2	1
UCEC	CD49b →	-0.459	-2.986	.005	.037	2	1
UCEC	Cyclin-B1 →	+1.046	+3.000	.001	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MEK1 by CCDC70 expression — UCEC

Explore this box plot interactively →