CCDC70

Across TCGA cell cohorts, CCDC70 mutation is significantly associated with the mutation status of many other genes, with 1,758 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCDC70-associated genes across cancer lineages are SLC15A1, NUDT7, and HDAC11. Each is linked with CCDC70 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC70-to-partner and partner-to-CCDC70 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC15A1 grouped by CCDC70-low versus CCDC70-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC70→partner) and Y-score (partner→CCDC70) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC15A1 →	+3.087	+4.392	.005	.005	1	3
LARGE_INTESTINE	NUDT7 →	+4.087	+5.044	.001	.001	1	3
LARGE_INTESTINE	HDAC11 →	+5.087	+4.523	.006	.006	1	3
OVARY	KDM5C →	+3.562	+4.684	.002	.002	1	3
OVARY	SMG7 →	+4.977	+4.415	.007	.007	1	3
LARGE_INTESTINE	TBX2 →	+3.672	+4.799	.002	.002	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,758 associations by consensus.

SLC15A1 by CCDC70 expression — LARGE_INTESTINE

Explore this box plot interactively →