Across TCGA pan-cancer cohorts, CCDC69 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of CCDC69’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where CCDC69 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CCDC69 is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

LSCC, LUAD, and COAD are the cancer types where CCDC69 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC69 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	−0.861	<.001	9	view →
LUAD	Female	II,III,IV	−0.793	<.001	9	view →
COAD	All	III,IV	−0.780	<.001	9	view →
PDAC	All	II,III,IV	−0.927	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: CCDC69 RNA expression & survival · all CCDC69 data types