CCDC66

Across TCGA patient cohorts, CCDC66 mutation is significantly associated with the RNA expression of many other genes, with 1,657 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC66-associated genes across cancer lineages are TRAJ5, GAPDHP17, and TMEM225. Each is linked with CCDC66 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC66-to-partner and partner-to-CCDC66 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ5 grouped by CCDC66-low versus CCDC66-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC66→partner) and Y-score (partner→CCDC66) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	TRAJ5 →	+0.676	+3.291	.002	.008	3	3
LGG	GAPDHP17 →	+0.039	+7.977	<.001	.007	3	2
READ	TMEM225 →	+0.114	+5.039	<.001	.008	3	2
READ	IGHD5-12 →	+1.742	+5.421	<.001	.005	3	2
LUAD	RNU6-502P →	+0.427	+5.631	<.001	.004	3	2
LUAD	GAGE2E →	+0.627	+6.197	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,657 associations by consensus.

TRAJ5 by CCDC66 expression — BLCA

Explore this box plot interactively →