CCDC66

Across TCGA patient cohorts, CCDC66 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC66-associated genes across cancer lineages are EGFR_pY1068, EGFR, and MEK1. Each is linked with CCDC66 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC66-to-partner and partner-to-CCDC66 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CCDC66-low versus CCDC66-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC66→partner) and Y-score (partner→CCDC66) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.228	-1.925	.011	.005	3	1
UCEC	EGFR →	-0.177	-2.321	.002	.001	3	1
UCEC	MEK1 →	+0.399	+2.584	.002	.010	3	1
UCEC	Notch1 →	+0.129	+3.335	.011	.005	3	1
UCEC	PCNA →	+0.231	+2.321	.002	.001	3	1
UCEC	Annexin-1 →	+0.472	+2.479	.012	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

EGFR_pY1068 by CCDC66 expression — UCEC

Explore this box plot interactively →