CCDC66

Across TCGA cell cohorts, CCDC66 mutation is significantly associated with the RNA expression of many other genes, with 333 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCDC66-associated genes across cancer lineages are RNASE8, NEU2, and PIWIL3. Each is linked with CCDC66 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC66-to-partner and partner-to-CCDC66 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNASE8 grouped by CCDC66-low versus CCDC66-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC66→partner) and Y-score (partner→CCDC66) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RNASE8 →	+0.030	+2.760	<.001	.003	3	2
OESOPHAGUS	NEU2 →	+0.146	+3.523	.001	.009	3	1
OESOPHAGUS	PIWIL3 →	+0.028	+4.115	<.001	.001	3	1
OESOPHAGUS	VHLL →	+0.073	+3.716	.007	.005	3	1
OESOPHAGUS	SPO11 →	+0.027	+3.392	.005	.007	3	1
SOFT_TISSUE	SLURP1 →	+0.043	+4.369	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 333 associations by consensus.

RNASE8 by CCDC66 expression — LARGE_INTESTINE

Explore this box plot interactively →