CCDC61

Across TCGA patient cohorts, CCDC61 mutation is significantly associated with the RNA expression of many other genes, with 601 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC61-associated genes across cancer lineages are RNA5SP86, ALKBH5, and TXN2. Each is linked with CCDC61 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC61-to-partner and partner-to-CCDC61 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP86 grouped by CCDC61-low versus CCDC61-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC61→partner) and Y-score (partner→CCDC61) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP86 →	+0.608	+2.599	<.001	.006	3	3
UCEC	ALKBH5 →	+0.465	+2.906	.004	.002	3	2
UCEC	TXN2 →	+0.333	+3.483	.009	.002	3	2
UCEC	ITGB1BP1 →	+0.396	+2.928	.004	.001	3	2
UCEC	CCDC163 →	+0.564	+3.337	<.001	.005	3	2
UCEC	PRADC1 →	+0.698	+2.823	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 601 associations by consensus.

RNA5SP86 by CCDC61 expression — UCEC

Explore this box plot interactively →