CCDC61

Across TCGA patient cohorts, CCDC61 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC61-associated genes across cancer lineages are JNK2, MEK1, and Myosin-IIa_pS1943. Each is linked with CCDC61 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC61-to-partner and partner-to-CCDC61 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by CCDC61-low versus CCDC61-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC61→partner) and Y-score (partner→CCDC61) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.272	+3.009	.006	.019	3	1
UCEC	MEK1 →	+0.465	+3.459	.011	.005	3	1
UCEC	Myosin-IIa_pS1943 →	+0.250	+3.169	.015	.019	3	1
UCEC	Myosin-IIa →	+0.190	+2.329	.041	.020	3	1
UCEC	Rab25 →	-0.433	-2.321	.009	.035	3	1
UCEC	SF2 →	-0.144	-2.308	.008	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

JNK2 by CCDC61 expression — UCEC

Explore this box plot interactively →