CCDC6

Across TCGA pan-cancer cohorts, CCDC6 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of CCDC6’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where CCDC6 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CCDC6 is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

LUAD, HNSC, and CCRCC are the cancer types where CCDC6 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC6 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	+0.355	<.001	9	view →
HNSC	Male	III,IV	−0.211	<.001	8	view →
CCRCC	All	II,III,IV	+0.138	<.001	6	view →
COAD	All	II,III,IV	−0.110	<.001	6	view →
LSCC	All	All	+0.151	<.001	4	view →
PDAC	Male	All	+0.229	.010	3	view →
OV	All	All	+0.514	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

CCDC6–LUAD

Open the LUAD breakdown →