CCDC6

Across TCGA patient cohorts, CCDC6 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC6-associated genes across cancer lineages are Caspase-7-cleavedD198, Bax, and c-Met. Each is linked with CCDC6 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC6-to-partner and partner-to-CCDC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CCDC6-low versus CCDC6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC6→partner) and Y-score (partner→CCDC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.995	+2.999	<.001	<.001	3	3
UCEC	Bax →	+0.238	+1.710	.006	.025	3	2
UCEC	c-Met →	-0.216	-2.301	.049	.005	3	2
UCEC	EGFR_pY1068 →	-0.279	-1.847	.002	.008	3	1
UCEC	eIF4E →	+0.234	+2.736	.002	<.001	3	1
UCEC	ERK2 →	+0.195	+1.502	.005	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Caspase-7-cleavedD198 by CCDC6 expression — UCEC

Explore this box plot interactively →