CCDC59

Across TCGA pan-cancer cohorts, CCDC59 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CCDC59 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CCDC59 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CCDC59 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where CCDC59 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.897	0.516	.008	13	view →
PDAC	OS	Quartile	All	0.718	0.959	.017	11	view →
HNSC	OS	Tertile	II,III,IV	1.000	0.893	.030	6	view →
CCRCC	OS	Median	II,III,IV	0.331	1.000	.010	5	view →
LUAD	OS	Quartile	III,IV	0.357	0.861	.013	4	view →
GBM	OS	Quartile	All	0.821	0.345	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CCDC59–LSCC (DFS)

Open the LSCC breakdown →