CCDC59

Across TCGA patient cohorts, CCDC59 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC59-associated genes across cancer lineages are Cyclin-E2, eIF4G, and A-Raf_pS299. Each is linked with CCDC59 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC59-to-partner and partner-to-CCDC59 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by CCDC59-low versus CCDC59-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC59→partner) and Y-score (partner→CCDC59) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.157	+1.700	.027	.044	3	2
UCEC	eIF4G →	+0.271	+1.700	.040	.044	3	1
UCEC	A-Raf_pS299 →	-0.135	-3.321	.007	.010	3	1
UCEC	FoxM1 →	+0.401	+4.000	<.001	<.001	3	1
UCEC	ACVRL1 →	-0.176	-2.986	.002	.035	3	1
UCEC	JNK2 →	+0.295	+3.486	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Cyclin-E2 by CCDC59 expression — UCEC

Explore this box plot interactively →