CCDC58

Across TCGA pan-cancer cohorts, CCDC58 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CCDC58 data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CCDC58 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CCDC58 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where CCDC58 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.429	0.946	<.001	54	view →
HNSC	OS	Quartile	All	0.134	1.000	.008	33	view →
PDAC	OS	Median	II,III,IV	0.608	0.385	.014	24	view →
UCEC	DFS	Median	III,IV	1.000	0.274	.001	20	view →
LSCC	DFS	Median	All	1.000	0.870	.003	20	view →
OV	DFS	Tertile	All	0.876	0.497	.024	12	view →
LUAD	DFS	Median	III,IV	0.432	0.925	.047	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CCDC58–CCRCC (DFS)

Open the CCRCC breakdown →