CCDC57

Across TCGA patient cohorts, CCDC57 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC57-associated genes across cancer lineages are ATM, Notch1, and Caspase-7-cleavedD198. Each is linked with CCDC57 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC57-to-partner and partner-to-CCDC57 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CCDC57-low versus CCDC57-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC57→partner) and Y-score (partner→CCDC57) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.541	-1.906	<.001	.015	3	3
UCEC	Notch1 →	+0.110	+2.183	.030	.033	3	2
COAD	Caspase-7-cleavedD198 →	+1.339	+3.186	<.001	.009	3	2
UCEC	4E-BP1 →	+0.219	+3.169	.024	.018	3	2
COAD	RAD51 →	+0.194	+3.330	.008	.005	3	2
UCEC	GSK3-a-b →	-0.097	-1.700	.047	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

ATM by CCDC57 expression — UCEC

Explore this box plot interactively →