CCDC51

Across TCGA pan-cancer cohorts, CCDC51 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CCDC51 data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CCDC51 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CCDC51 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where CCDC51 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.839	0.615	.006	27	view →
CCRCC	DFS	Quartile	III,IV	0.359	0.773	.005	22	view →
PDAC	DFS	Tertile	All	0.735	0.859	.005	6	view →
LSCC	OS	Tertile	II,III,IV	0.941	0.637	.021	6	view →
UCEC	DFS	Tertile	All	0.737	0.914	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CCDC51–HNSC (OS)

Open the HNSC breakdown →